Disease-Associated Prion Protein Elicits Immunoglobulin M Responses In Vivo
نویسندگان
چکیده
منابع مشابه
Disease-associated prion protein elicits immunoglobulin M responses in vivo.
Prion diseases such as Creutzfeldt-Jakob disease are believed to result from the misfolding of a widely expressed normal cellular prion protein, PrPc. The resulting disease-associated isoforms, PrP(Sc), have much higher beta-sheet content, are insoluble in detergents, and acquire relative resistance to proteases. Although known to be highly aggregated and to form amyloid fibrils, the molecular ...
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ژورنال
عنوان ژورنال: Molecular Medicine
سال: 2004
ISSN: 1076-1551,1528-3658
DOI: 10.2119/2004-00027.tayebi